Cell Signaling Macc1 (D2k7v) Rabbit mAb

Name: Cell Signaling Macc1 (D2k7v) Rabbit mAb
SKU: CSIG-86290S
Price: 354.51 USD

List Price $354.51 Your Price $354.51

Cell Signaling Macc1 (D2k7v) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-86290S

MFG.PART: 86290S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	97
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	MACC1 (D2K7V) Rabbit mAb recognizes endogenous levels of total MACC1 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro442 of human MACC1 protein.
Background	The gene encoding metastasis-associated in colon cancer-1 (MACC1) was identified based on its overexpression in metastatic colon carcinoma (1), and was later shown to be overexpressed in multiple human cancers, including hepatocellular carcinoma, gastric cancer, head and neck cancer, and breast cancer (2-4). MACC1 regulates HGF/MET and β-catenin signaling, resulting in increased proliferation, migration and invasion, and initiation of the epithelial-mesenchymal transition (EMT) (2). Researchers have shown that MACC1 can be used as a prognostic indicator in solid tumors, and that it has potential as a therapeutic target (5).