Cell Signaling Steap1 (D8b2v) Rabbit mAb

Name: Cell Signaling Steap1 (D8b2v) Rabbit mAb
SKU: CSIG-88677S
Price: 354.51 USD

List Price $354.51 Your Price $354.51

Cell Signaling Steap1 (D8b2v) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-88677S

MFG.PART: 88677S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H R
Sensitivity	Endogenous
Molecular Weight (kDa)	30
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	STEAP1 (D8B2V) Rabbit mAb recognizes endogenous levels of total STEAP1 protein. This antibody also recognizes overexpressed STEAP1B isoform 1 protein and may recognize endogenous STEAP1B isoform 1 protein.
Species Reactivity	Human, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human STEAP1 protein.
Background	Six transmembrane epithelial antigen of the prostate 1 (STEAP1) is a transmembrane protein abundantly expressed in normal prostate epithelial cells (1). It is a metalloreductase that reduces Fe3+ to Fe2+ and Cu2+ to Cu1+ (2). STEAP1 is also reportedly overexpressed in multiple tumor types, and has been used as a cell surface biomarker for prostate cancer and Ewings sarcoma (3-6). Peptides derived from STEAP1 protein have been shown to induce an antigen-specific cytotoxic T lymphocyte (CTL) response that can kill tumor cells expressing STEAP1 (7). These finding are the basis for research studies examining the efficacy of antibody-drug conjugates (ADCs) targeting STEAP1 (8,9).