Cell Signaling Gapdh (D16h11) Xp Rabbit mAb (Hrp Conjugate)

Name: Cell Signaling Gapdh (D16h11) Xp Rabbit mAb (Hrp Conjugate)
SKU: CSIG-8884S
Price: 469.65 USD

List Price $469.65 Your Price $469.65

Cell Signaling Gapdh (D16h11) Xp Rabbit mAb (Hrp Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-8884S

MFG.PART: 8884S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	37
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 136 mm NaCl, 2.6 mm KCI, 12 mm sodium phosphate (pH 7.4) dibasic, 2 mg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibodies.
Specificity/Sensitivity	GAPDH (D16H11) XP® Rabbit mAb (HRP Conjugate) detects endogenous levels of total GAPDH protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human GAPDH protein.
Background	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the phosphorylation of glyceraldehyde-3-phosphate during glycolysis. Though differentially expressed from tissue to tissue (1), GAPDH is thought to be a constitutively expressed housekeeping protein. For this reason, GAPDH mRNA and protein levels are often measured as controls in experiments quantifying specific changes in expression of other targets. Recent work has elucidated roles for GAPDH in apoptosis (2), gene expression (3), and nuclear transport (4). GAPDH may also play a role in neurodegenerative pathologies such as Huntington and Alzheimers diseases (4,5).