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Cell Signaling Icos (D1k2t) Rabbit mAb (Ihc Specific)
List Price
$360.57
Your Price
$360.57
Cell Signaling Icos (D1k2t) Rabbit mAb (Ihc Specific) - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-89601S
MFG.PART:
89601S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 25-40 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {IHC Leica Bond: 1:100 - 1:400, Immunohistochemistry (Paraffin): 1:100 - 1:400} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #39740. |
| Specificity/Sensitivity | ICOS (D1K2T™) Rabbit mAb recognizes endogenous levels of total ICOS protein. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human ICOS protein. |
| Background | ICOS (Inducible Co-Stimulator, CD278) is a member of the CD28 family that regulates T cell activity and immune responses (1). The ICOS protein contains an extracellular IgV-like domain, a transmembrane domain, and an intracellular domain with a YMFM motif (1-2). ICOS is primarily expressed on activated CD4+ and CD8+ T cells (1). Upon binding to its ligand, ICOS potentiates the T cell response to antigen through activation of the PI3K signaling pathway (3). In addition to enhancing T cell activation and proliferation, ICOS plays an important role in the regulation of T follicular helper cells (4). Research studies suggest that ICOS is a potential therapeutic target, and could serve as a prognostic biomarker for neoplastic therapy involving CTLA-4 blockade (5-7). |
| SKU | CSIG-89601S |
|---|---|
| Featured | No |
| Supplier Part Number | 89601S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |