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Cell Signaling Mers-Cov Envelope Protein (E8x6r) Rabbit mAb
List Price $354.51 Your Price $354.51
Cell Signaling Mers-Cov Envelope Protein (E8x6r) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART: CSIG-89952S
MFG.PART: 89952S
UNSPSC: 12352203
Manufacturer: Cell Signaling
| Size | 100 µl |
| Reactivity | Vir |
| Sensitivity | Transfected Only |
| Molecular Weight (kDa) | 12 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | MERS-CoV Envelope Protein (E8X6R) Rabbit mAb recognizes transfected levels of total MERS-CoV envelope protein. |
| Species Reactivity | Virus |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro75 of MERS-CoV envelope protein. |
| Background | Middle East Respiratory Syndrome (MERS) is a contagious viral respiratory infection, whose causative agent was identified as the MERS-related coronavirus (MERS-CoV) (1,2). MERS-CoV is a single-stranded mRNA betacoronavirus. Similar to other infectious coronaviruses (e.g., SARS-CoV-2), the MERS-CoV genome encodes four key structural proteins (spike, envelope, membrane, and nucleocapsid) that make up the virion particle, in addition to at least 10 smaller open reading frames (ORFs) that encode the non-structural (accessory) proteins involved in viral replication (3,4). The MERS envelope protein (E) is the smallest of the structural proteins, and is abundantly expressed in the host cell during viral replication, despite only a fraction of synthesized E protein ultimately being incorporated into new viral particles (5). As in other betacoronaviruses, the MERS E protein likely functions as an ion channel (viroporin), involved in transmembrane molecular transport (6). Within infected host cells, E protein is largely localized to endoplasmic reticulum, Golgi, and related intermediate structures (e.g., ERGIC), consistent with a functionally important role in assembly, budding, and intracellular trafficking of new virion particles (5). This is supported by studies showing that MERS virions were incapable of replication after deletion of the gene encoding the E protein (7). |
| SKU | CSIG-89952S |
|---|---|
| Supplier Part Number | 89952S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |