Cell Signaling Jam-A (E8d2n) Xp® Rabbit mAb

Name: Cell Signaling Jam-A (E8d2n) Xp® Rabbit mAb
SKU: CSIG-92435T
Price: 179.78 USD

List Price $179.78 Your Price $179.78

Cell Signaling Jam-A (E8d2n) Xp® Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-92435T

MFG.PART: 92435T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	20 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	40
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunohistochemistry (Paraffin): 1:800 - 1:3200}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	JAM-A (E8D2N) XP® Rabbit mAb recognizes endogenous levels of total JAM-A protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the central sequence of human JAM-A protein.
Background	Junctional Adhesion Molecule-A/F11 Receptor (JAM-A/F11R) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. JAM-A regulates multiple cellular processes, including tight junction assembly, epithelial-mesenchymal transition (EMT), leukocyte migration, virus binding, platelet activation, and angiogenesis. Aberrant expression of JAM-A is correlated with poor patient prognosis in several human cancers (1,2). In a mouse model of atherosclerosis, an antagonistic peptide that inhibits JAM-A-expressing platelets from interacting with inflamed endothelial cells reduces atherosclerotic plaque formation (3).