Cell Signaling 4-1bb/Cd137/Tnfrsf9 (D2z4y) Rabbit mAb (PE Conjugate)

Name: Cell Signaling 4-1bb/Cd137/Tnfrsf9 (D2z4y) Rabbit mAb (PE Conjugate)
SKU: CSIG-95663S
Price: 469.65 USD

List Price $469.65 Your Price $469.65

Cell Signaling 4-1bb/Cd137/Tnfrsf9 (D2z4y) Rabbit mAb (PE Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-95663S

MFG.PART: 95663S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:50, Flow Cytometry (Live): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibodies. Protect from light. Do not freeze.
Specificity/Sensitivity	4-1BB/CD137/TNFRSF9 (D2Z4Y) Rabbit mAb (PE Conjugate) recognizes endogenous levels of total 4-1BB/CD137/TNFRSF9 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to the extracellular domain of human 4-1BB/CD137/TNFRSF9 protein.
Background	TNFRSF9 is a member of the tumor necrosis factor receptor superfamily (1,2). It is also called 4-1BB or CD137 (1, 2). 4-1BB/CD137/TNFRSF9 is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells (2-5). The ligand 4-1BBL/CD137L/TNFSF9 on antigen presenting cells binds to 4-1BB/CD137/TNFRSF9 and costimulates the activation of T cells (5). The binding of agonistic antibodies to 4-1BB/CD137/TNFRSF9 also leads to costimulation for T cell activation (5). Studies have shown the effectiveness of targeting 4-1BB/CD137/TNFRSF9 by its agonistic antibodies in cancer immunotherapy (6).

Specifications