Cell Signaling Mzb1 (E8v4n) Rabbit mAb

Name: Cell Signaling Mzb1 (E8v4n) Rabbit mAb
SKU: CSIG-96905S
Price: 354.51 USD

List Price $354.51 Your Price $354.51

Cell Signaling Mzb1 (E8v4n) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-96905S

MFG.PART: 96905S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	20
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	MZB1 (E8V4N) Rabbit mAb recognizes endogenous levels of total MZB1 protein.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu113 of human MZB1 protein.
Background	Marginal zone B- and B1-cell-specific protein (MZB1) is an ER-resident chaperone protein that is expressed by marginal zone B cells and during plasma cell differentiation (1,2). MZB1 possesses oxidoreductase activity that assists in the proper folding, assembly, and secretion of mature IgM by plasma cells (1,3). Research studies have demonstrated that loss of MZB1 expression compromises antibody secretion and humoral immune responses (4).