Cell Signaling Ncam1 (Cd56) (123c3) Mouse mAb (BSA And Azide Free)

Name: Cell Signaling Ncam1 (Cd56) (123c3) Mouse mAb (BSA And Azide Free)
SKU: CSIG-97174SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Ncam1 (Cd56) (123c3) Mouse mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-97174SF

MFG.PART: 97174SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	120 to 220
Source/Isotype	Mouse IgG1
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #3576.
Specificity/Sensitivity	NCAM (CD56) (123C3) Mouse mAb (BSA and Azide Free) detects endogenous levels of total CD56 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing BALB/c mice with a membrane preparation of a small cell lung carcinoma specimen.
Background	NCAM (neural cell adhesion molecule, CD56) is an adhesion glycoprotein with five extracellular immunoglobulin-like domains followed by two fibronectin type III repeats. Structural diversity is introduced by alternative splicing resulting in different cytoplasmic domains (1). NCAM mediates neuronal attachment, neurite extension, and cell-cell interactions through homo and heterophilic interactions. PSA (polysialic acid) post-translationally modifies NCAM and increases the metastatic potential of small cell lung carcinoma, Wilms+ tumor, neuroblastoma, and rhabdomyosarcoma (2). CD56 is commonly used along with CD3 and CD16 to identify human natural killer (NK) cells (mouse NK cells do not express CD56) (3). Human NK cells are CD3-CD56+. The large subset with high CD16 expression are mature cytotoxic NK cells, while those with low CD16 expression are immature precursors and cytokine producers (4,5).