Cell Signaling Ceruloplasmin (D7q5w) Rabbit mAb

Name: Cell Signaling Ceruloplasmin (D7q5w) Rabbit mAb
SKU: CSIG-98971S
Price: 354.51 USD

List Price $354.51 Your Price $354.51

Cell Signaling Ceruloplasmin (D7q5w) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-98971S

MFG.PART: 98971S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	140
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:200}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Ceroluplasmin (D7Q5W) Rabbit mAb recognizes endogenous levels of total Ceruloplasmin protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Phe727 of human Ceruloplasmin protein.
Background	Ceruloplasmin is a copper-binding glycoprotein with ferroxidase activity. It oxidizes Fe2+ to Fe3+, facilitating iron transport across the cell membrane (1). Mutation in Ceruloplasmin causes aceruloplasminemia, an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs, resulting in retinal degeneration, diabetes mellitus and neurological disturbances (2,3). Ceruloplasmin level in serum has been explored as a diagnostic marker for Wilson disease and ischemic heart disease (4,5).