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AG Scientific Lactacystin, 200 UG
List Price $228.25 Your Price $228.25
AG Scientific Lactacystin (200 μg) cell permeable, specific, irrev inhibitor of 20S proteasome & Cathepsin A. Irrev binds to N-terminal threonine residue on active site of catalytic B subunit of 20S - AG (Additional S&H or Hazmat Fees May Apply)
NETA PART: RPI-L-1147-200UG
MFG.PART: L-1147-200UG
UNSPSC: 12352200
Manufacturer: AG Scientific
AG Scientific
Lactacystin is a microbial metabolite of Streptomyces strains and acts as a cell permeable, specific, and irreversible inhibitor of 20S proteasome and lysosomal enzyme, Cathepsin A. It irreversibly binds to N-terminal threonine residue on active site of catalytic B subunit of 20S proteasome and therefore blocks proteolytic activity.
The metabolite blocks the cell cycle and induces neurite outgrowth in a murine neuroblastoma cell line, Neuro-2a. It inhibits cell cycle progression in both the g0/g1 and g2/M phases of the cell cycle. Treatment of Lactacystin in Neuro-2a cells displays bipolar morphology and becomes progressively more multipolar.
Lactacystin induces apoptosis in human monoblastic U937, confirming DNA fragmentation.
| SKU | RPI-L-1147-200UG |
|---|---|
| Supplier Part Number | L-1147-200UG |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | AG Scientific |
| MSDS URL | Click here |
| Temperature | -20°C |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Japan |
| ProductLine | AG |
| Qty | 1 |
| MinOrderQty | 1 |
| Width | 8 |
| Depth | 8 |
| Height | 8 |
| Weight | 7.000000 |
| Lead Time | 20 |
| Hazardous | N |
| CAS Number | 133343-34-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |