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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| B, Ca, F, Fe, Fg, Gt, H, M, Po, R, Rb | ICC, IH(P), WB | M | Ascites | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MAB1572 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Parvalbumin Antibody |
| Background Information | Parvalbumin is a calcium binding albumin protein. It has three EF hand motifs and is structurally related to calmodulin and troponin C. Parvalbumin is localised in fast-contracting muscles, where its levels are highest, and in the brain and some endocrine tissues. Parvalbumin is present in GABAergic interneurons in the nervous system, predominantly expressed by chandelier and basket cells in the cortex. |
| Product Information | |
|---|---|
| Format | Ascites |
| Control |
|
| Presentation | Ascites mouse monoclonal IgG1 liquid |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Parvalbumin Antibody is an antibody against Parvalbumin for use in IC, IH(P) & WB. |
| Key Applications |
|
| Application Notes | Immunohistochemistry: A previous lot was used by indirect immunoperoxidase at 1:1,000-1:2,000 dilution. The antibody works on formalin fixed, paraffin embedded tissue sections of rat cerebellum from a previous lot. Fixation does not appear to affect MAB1572’s ability to detect parvalbumin. Immunocytochemistry: A previous lot of this antibody was used on cultured neurons. Optimal working dilutions must be determined by the end user. |
| Biological Information | |
|---|---|
| Immunogen | Parvalbumin purified from frog muscle |
| Clone | PARV-19 |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Mouse |
| Specificity | Parvalbumin. The antibody will react with parvalbumin from brain and muscle. By immunoblot it recognizes a protein of 12 kDa. The antibody is directed against an epitope at the first Ca+2-binding site and specifically stains the Ca+2 -bound form of parvalbumin. |
| Isotype | IgG1 |
| Species Reactivity |
|
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. |
| Gene Symbol |
|
| Purification Method | Unpurified |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P20472 # In muscle, the calcium-binding protein parvalbumin is thought to be involved in muscle relaxation. SIZE: 110 amino acids; 12059 Da SIMILARITY: SwissProt: P20472 ## Belongs to the parvalbumin family. & Contains 2 EF-hand domains. MISCELLANEOUS: This protein binds two calcium ions. |
| Molecular Weight | 12 kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Routinely evaluated by Western Blot on mouse brain lysate. Western Blot Analysis: 1:1000 dilution of this lot detected Parvalbumin on 10 μg of mouse brain lysate. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at -20ºC from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µL |