Takara B/B Homodimerizer \5 mg

The B/B Homodimerizer is a membrane-permeant ligand that causes homodimerization of proteins fused to dimerization domain B (DmrB)—provided in the iDimerize Inducible Homodimer System (Cat. No. 635068). NOTE: The B/B Homodimerizer is identical to the AP20187 ligand previously supplied in the ARGENT Regulated Homodimerization Kit from ARIAD Pharmaceuticals, Inc.

Signal transduction example 2.Inducible mouse model for prostate cancer. iDimerize Inducible Homodimer technology was used to characterize the role of different FGF receptor subtypes (FGFR1andFGFR2) in prostate cancer. Transgenic mice (which express conditionally active alleles ofFGFR1orFGFR2in prostate tissue) were treated with B/B Homodimerizer and monitored for prostate cancer.FGFR1, but notFGFR2, was found to play a role in prostate cancer development [Freeman, K. W.,et Al. (2003)Cancer Res.63(23):8256–8563].

Exploiting fas-mediated apoptosis to induce programmed cell death.Fas-mediated apoptosis is triggered by trimerization of the fas receptor (FasR) via its interaction with the fas ligand (FasL) on an adjacent cell (left). This FasR trimerization event activates the caspase 8 pathway. In the MaFIA mouse model, the fas death domain is fused to two repeats of a dimerization domain and expressed from a myeloid-specific promoter. Apoptosis of macrophage cells in this mouse is induced by treatment with B/B Homodimerizer (AP20187) (right).