Cell Signaling Hsp60 (D6f1) Xp Rabbit mAb (Hrp Conjugate)

Name: Cell Signaling Hsp60 (D6f1) Xp Rabbit mAb (Hrp Conjugate)
SKU: CSIG-46611S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Hsp60 (D6f1) Xp Rabbit mAb (Hrp Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-46611S

MFG.PART: 46611S

UNSPSC: 41116012

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Hm Mk X Z B Pg
Sensitivity	Endogenous
Molecular Weight (kDa)	60
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 136 mM NaCl, 2.6 mM KCl, 12 mM sodium phosphate (pH 7.4) dibasic, 2 mg/ml BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	HSP60 (D6F1) XP® Rabbit mAb (HRP Conjugate) recognizes endogenous levels of total HSP60 protein.
Species Reactivity	Human, Mouse, Rat, Hamster, Monkey, Xenopus, Zebrafish, Bovine, Pig
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Trp68 of human HSP60 protein.
Background	In both prokaryotic and eukaryotic cells the misfolding and aggregation of proteins during biogenesis and under conditions of cellular stress are prevented by molecular chaperones (1-3). HSP60 has primarily been known as a mitochondrial protein that is important for folding key proteins after import into the mitochondria (4). Research studies have shown that a significant amount of HSP60 is also present in the cytosol of many cells, and that it is induced by stress, inflammatory and immune responses, and autoantibodies correlated with Alzheimers, coronary artery diseases, MS, and diabetes (5-8).

Specifications