Revvity 5-CT,

Revvity 5-CT is a tryptamine derivative closely related to serotonin. 5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 receptors, as well as at the 5-HT2, 5-HT3, 5-HT6 receptors with lower affinity. These receptors are part of a group of serotonin G-protein coupled receptors (GPCRs) found in the central and peripheral nervous systems, and modulate the release of neurotransmitters and hormones. 5-HT receptors are the pharmacological target of many antidepressants, antipsychotic, anti-migraine, and other pharmaceutical drugs. We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays. Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. References for NET1188: G. Sataa, B. Duszyska, T. Lenda, G. Nowak, A. J. Bojarski. Allosteric Inhibition of Serotonin 5-HT7 Receptors by Zinc Ions, Molecular Neurobiology, 2017, pages 1-14. K.W. Andressen, A. H. Ulsund, K. A. Krobert, M. J. Lohse, M. B?nemann, F. O. Levy, Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gs upon receptor activation, FASEB, 2017. - PEMSD (Additional S&H or Hazmat Fees May Apply)