Revvity Lysergic Acid Diethylamide, -, 250uCi (9.25MBq)

Revvity Lysergic Acid Diethylamide (LSD) is a psychedelic drug that acts as an agonist at dopamine D2 receptors and serotonin receptors 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT5B and 5-HT6. We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays. Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. References for NET638: Teresa Riccioni, Fabio Bordi, Patrizia Minetti, Gilberto Spadoni, Hyung-Mun Yun, Bo-Hye IM, Giorgio Tarzia, Hyewhon Rhim, Franco Borsini, ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors, In European Journal of Pharmacology, Volume 661, Issues 1-3, 2011, Pages 8-14. Rigmor Stain-Malmgren, Bengt F Kjellman, Anna ?berg-Wistedt, Platelet serotonergic functions and light therapy in seasonal affective disorder, In Psychiatry Research, Volume 78, Issue 3, 1998, Pages 163-172. - PEMSD (Additional S&H or Hazmat Fees May Apply)