Genscriptmonorab Anti-Humanized Vhh Affinity Resin; 1mL Resin (Total 2 mL)

CamelidVHH Antibody (also called single-domain antibody, sdAb or Nanobody by Ablynx)is a peptide chain about 110 amino acids in length, containing one variabledomain of a heavy-chain antibody (a VHH fragment). Like a whole antibody, the camelidVHH antibody is able to bind selectively to a specific antigen. This single-domainantibody has a broad range of applications in biotechnical and therapeutic researchfields due to its small size, simple production and high affinity. However, their sequences may increase the risk of immunogenicity andanti-drug antibody (ADA) development in humans, and thus, sdAbs are routinelyhumanized during development.
GenScript’s MonoRab™ Anti- Humanized VHH AffinityResin FF (Cat. No. L00951) is designed for purification of humanized VHHsingle domain antibody from commonly used protein expression systems such as bacteria,yeast and mammalian cells. The VHH single domain antibody in cell lysate can specificallybind to the Anti- Humanized VHH monoclonal antibody coupled to the resin. Nonspecific bindingreactions are eliminated by stringent washing steps, and the purified targetprotein is eluted with a high recovery rate. Table 1 lists the main characteristicsof GenScript’s MonoRab™ Anti- Humanized VHH Affinity Resin FF.