Sigma-Aldrich Thiostrepton, 1g

Sigma-Aldrich Calbiochem Thiostrepton, 1 g Net Content, C72H85N19O18S5, Powder Form, Light Yellow, >=98 %, 2 to 8 deg C, Melting Point: 246 to 256 deg C, FOXM1 Inhibitor I, Thiostrepton - CAS 1393-48-2 - Calbiochem, 1.664 g/mol Molecular Weight, 1393-48-2 CAS Number, HPLC Grade. A thiazole-containing peptide anti-biotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit. Inhibits the function of elongation factor g (EF-g) and the dissociation of EF-g from the ribosome. The thiostrepton-resistant gene is also commonly used as a selective marker for recombinant DNA/plasmid technologies. A thiazole-containing polypeptide anti-biotic isolated from Streptomyces azureus. Inhibits bacterial protein synthesis and ribosomal GTPase activity by binding non-covalently, but virtually irreversibly, to the 23S rRNA in the GTPase center of the 50S subunit. Thiostrepton binding directly prevents binding to the ribosome of elongation factor g (EF-g), which also binds specifically to the 23S rRNA. Thiostrepton has proved useful in elucidating the molecular mechanisms of translation, particularly of ribosomal translocation. It is also used for selection, in bacteria of Streptomyces sp., of vectors containing the tsr gene (S. azureus), which encode a 23S rRNA methylase whose action prevents thiostrepton from binding to ribosomes - SIALGSK (Additional S&H or Hazmat Fees May Apply)