Revvity Htrf Mi-1061 Red Ligand Is A Derivative Of

Revvity Trf Mi-1061 Red Ligand Is Primarily Intended To Perform Affinity Binding Curves To Mdm2 Protein Using Htrf® Technology. Mdm2, Also Known As Murine Double Minute 2, Is Involved In Many Biological Processes And Is Closely Associated With Dna Repair, Cell Cycle Arrest, Apoptosis, And The Occurrence Of Many Diseases. Mdm2 Is One Of The Most Popular E3 Ligases Which Is Recruited By Bifunctional Proteolysis-Targeting Chimeras (Protacs) To Induce Ubiquitination And Subsequent Proteasomal Degradation Of A Targeted Protein. Mdm2 Interacts With Several Proteins To Form The Functional E3 Ubiquitin Ligase Complex,In Which Mdm2 Functions As A Substrate Receptor Of The E3 Ubiquitin Ligase Complex And Targets Various Proteins As Targeted-Protein For Proteolysis. Identifying New Mdm2 Ligands Is Therefore A Way To Control Biological Processes Involved In Oncology, Neurodegenerative, Or Metabolic Diseases By Inducing The Proteasomal-Dependent Degradation Of Proteins Like P53. Htrf Mi-1061 Red Ligand Binding Assays Can Be Used In Association With The Htrf Mdm2 Binding Kit (#Perkinelmer 64bdmdm2peg/H) For Cooperativity Binding Studies To Monitor The Effect Of Protac Protein Substrate On The Kd Of Htrf Mi-1061 Red Ligand For Mdm2 Protein, Enabling Accurate Analysis Of Cooperative Effect Monitored With The Htrf Mdm2 Binding Kit. - PEGSK (Additional S&H Or Hazmat Fees May Apply)