Revvity Human Il23/Il23r Binding

Revvity Il23 Is Part Of The Response Against Infection, As It Upregulates The Expression Of Mmp9 (Matrix Metalloprotease 9), Increases Angiogenesis, And Reduces Cd8 T Cell Infiltration Into Tumors. In Oncology And Immuno-Oncology, Il23 Has Been Studied For Its Effects On T Cell Infiltration And Its Promotion On Th17 Cell Development. Anti Il23 Antibodies Have Also Been Developed For The Treatment Of Crohns Disease And Psoriasis. Il23 Is A Heterodimeric Cytokine Composed Of P19 And P40 Subunits, And Which Binds The Heterodimeric Il23r, Il12r1 Complex. The Human Il23-Il23r Assay Is Highly Specific For Il23/Il23r, And Hence Is Especially Suitable For The Discovery And Characterization Of Anti P19 Antibodies - PEGSK (Additional S&H Or Hazmat Fees May Apply)