Sigma-Aldrich Ethyl Acetoacetate

Vapor Density

4.48 (vs air)

Quality Level

200

Vapor Pressure

1 mmHg ( 28.5 °C)

Grade

puriss. p.a.

Assay

≥99.0% (GC)

Autoignition Temp.

580 °F

Expl. Lim.

9.5 %

Impurities

≤0.5% water

Refractive Index

n20/D 1.419

Bp

181 °C (lit.)

Related Categories

Organic Building Blocks

Application

Ethyl acetoacetate can be used as a reactant in the synthesis of:

• Knoevenagel condensation products by reacting with α-alkylideneacetoacetate and aliphatic, aromatic, heteroaromatic aldehydes.
• Michael adducts, via Michael addition reaction with chalcones and azachalcones in the presence of a base catalyst.
• Substituted nicotinic acid derivatives by treating with α, β-unsaturated oximes via Michael addition followed by ring closure reaction.

It can be also utilized as a reactant in the transesterification and asymmetric hydrogenation reactions to produce valuable products.[5]

Storage Class

10 - Combustible liquids

Wgk_Germany

WGK 1

Flash_Point_F

164.3 °F - closed cup

Flash_Point_C

73.5 °C - closed cup

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter