Sigma-Aldrich 2,2-Bis(hydroxymethyl)propionic acid

2,2-Bis(hydroxymethyl)propionic acid based fourth generation tridendron dendrimer having 48 hydroxyl groups was synthesized[1].

2,2-Bis(hydroxymethyl)propionic acid is commonly used as an AB₂ monomer for the synthesis of hyperbranched (hb) polymers and dendrimers.[2][3]

2,2-Bis(hydroxymethyl)propionic acid was used in the synthesis and characterization studies of polyurethane dispersion modified with polymethylsiloxane (Si-PUD) and its nanocomposites incorporated with clays[4].2,2-Bis(hydroxymethyl)propionic acid based dendrimers have potent applications as delivery systems for potent anticancer drugs such as cisplatin and doxorubicin, as well as agents for both boron neutron capture therapy and photodynamic therapy[5].

Simple derivatives of this acid have been used to construct dendritic architectures via the "click" azide-acetylene cycloaddition.[6]

DMPA is a registered trademark of GEO Specialty Chemicals, Inc.