Sigma-Aldrich Aminoacetaldehyde dimethyl acetal

Aminoacetaldehyde dimethyl acetal reacts with sulfone, followed by hydrolysis and reductive amination by adding desired piperazine derivative to yield piperazine derivatives of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine[1].

Aminoacetaldehyde dimethyl acetal is used as a building block for the synthesis of various acylated and sufonylated oxyenamides.[2] [3]

Aminoacetaldehyde dimethyl acetal was used in a study to develop a fluorescent substrate for aldehyde dehydrogenase[4]. It was used in preparation of chitosan-dendrimer hybrids having various functional groups such as carboxyl, ester and poly(ethylene glycol)[5]. It was used in an efficient 3-step synthesis of a bicyclic proline analog from L-ascorbic acid[6] and in 3-component reaction catalyzed by MgClO₄ leading to α-aminophosphonates[7].