Sigma-Aldrich Ethyl Bromoacetate Reagent

Ethyl bromoacetate is commonly used in organic synthesis as an alkylating agent and acylation reagent.[1][2] Ethyl bromoacetate on derivatisation reaction with p-t-butyl calix[4]arene yields 1,3-diester substituted calix[4]arene[3]. It also undergoes Suzuki type cross-coupling reactions with arylboronic acids cocatalyzed by copper(I) oxide[4].

Ethyl bromoacetate was used to prepare reversibly photoresponsive coumarin-stabilized polymeric nanoparticles in an aqueous medium, which act as a detectable drug carrier[5].