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Millipore Active, N-Terminal His6 Tagged Recombinant Full-Length Human Rsk1, For Use In Kinase Assays. - Mill (Additional S&H or Hazmat Fees May Apply)
N-terminal His6 tagged recombinant full-length human RSK1
Product Information
Quality Level
MQ100
Applications
Application
Active, N-terminal His6 tagged recombinant full-length human RSK1, for use in Kinase Assays.
Key Applications
Kinase Assay
Biological Information
Source
expressed in Sf21 cells
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_001006665.1
NM_002953.3
Entrez Gene Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Gene Symbol
RPS6KA1
HU-1
RSK-1
MAPKAPK1A
RSK
pp90RSK1
p90S6K
RSK1
Protein Target
Rsk1
Purification Method
Ni2+/NTA-agarose
Target Sub-Family
AGC
UniProt Number
Q15418
UniProt Summary
FUNCTION: SwissProt: Q15418 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. COFACTOR: Magnesium. SIZE: 735 amino acids; 82723 Da SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation. PTM: Autophosphorylated on Ser-380, as part of the activation process. SIMILARITY: SwissProt: Q15418 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
Molecular Weight
84kDa
Product Usage Statements
Quality Assurance
routinely evaluated by phosphorylation of MAPKAP Kinase 2 Substrate Peptide
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
6 months at -70C
Packaging Information
Material Size
10 µg
Material Package
Also available in 250μg size as catalog # 14-509M - Call for pricing and availability.
