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Human Midkine (MK) is a new member of the heparin-binding neurotrophic factor family. MK and PTN (Pleiotrophin) are structural homologs, and are highly conserved among species. MK plays important roles in development and carcinogensis and has several important biological effects, including promotion of neurite extension and neuronal survival. Recombinant Midkine is a 13.4 kDa protein, comprising of 123 amino acid residues.
Product Information
Presentation
Lyophilized from 0.4x PBS, pH 7.4.
Quality Level
MQ100
Applications
Key Applications
Positive Control
Biological Information
Purity
Greater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per mg of MK.
Source
E.coli
Entrez Gene Number
NM_001012333.1
NM_001012334.1
NM_002391.3
Gene Symbol
MDK
ARAP
FLJ27379
MK1
NEGF2
MK
midkine
UniProt Number
P21741
UniProt Summary
FUNCTION: SwissProt: P21741 # Has heparin binding activity, and growth promoting activity. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). SIZE: 143 amino acids; 15585 Da SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Secreted. SIMILARITY: SwissProt: P21741 ## Belongs to the pleiotrophin family.
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
The lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C. After a quick spin, reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into water or other buffered solutions. Reconstitute MK should be stored in undiluted aliquots at -20°C for up to 6 months.
