Cell Signaling Edc3 (D2t7u) Rabbit mAb

Name: Cell Signaling Edc3 (D2t7u) Rabbit mAb
SKU: CSIG-14495S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Edc3 (D2t7u) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-14495S

MFG.PART: 14495S

UNSPSC: 41105803

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	62
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	EDC3 (D2T7U) Rabbit mAb recognizes endogenous levels of total EDC3 protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly322 of human EDC3 protein.
Background	Enhancer of mRNA decapping 3 (EDC3) was originally identified from Saccharomyces cerevisiae as a protein essential to mRNA decapping prior to 5’-3’ mRNA degradation (1). In human cells, EDC3 is found within cytoplasmic processing (P) bodies as part of complexes that include DCP1, DCP2, EDC4/Ge-1, and DDX6/RCK (2). EDC3 and DCP2 interact with TTP, an activator of AU-rich-element (ARE)-mediated decay pathway, to promote decapping and degradation of ARE mRNA (2). In addition, research studies indicate that EDC3 may play a role in the premature termination of RNA polymerase II transcription (3).

Specifications