Cell Signaling Imp2 (D4r2f) Rabbit mAb

Name: Cell Signaling Imp2 (D4r2f) Rabbit mAb
SKU: CSIG-14672S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Imp2 (D4r2f) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-14672S

MFG.PART: 14672S

UNSPSC: 41105803

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	66, 62
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	IMP2 (D4R2F) Rabbit mAb recognizes endogenous levels of total IMP2 protein. This antibody recognizes both the 66 kDa isoform 1 and the 62 kDa isoform 2. This antibody may cross-react with an unidentified protein of 40 kDa.
Species Reactivity	Human, Mouse, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human IMP2 protein.
Background	Insulin-like growth factor-II mRNA-binding proteins (IMPs) belong to a family of zipcode-binding proteins (1,2). Three members of this family, IMP1, IMP2, and IMP3, have been identified (1,2). They contain two RNA recognition motifs, four K homology domains, and were found to function in mRNA localization, turnover, and translation control (1,2). Research studies have implicated these proteins in a variety of physiological and pathological processes, such as growth and development (3), testicular neoplasia (4), and melanocytic neoplasia (5).A well-characterized polymorphism in the corresponding IGF2BP2 gene is associated with susceptibility to type 2 diabetes in specific ethnic populations (6).

Specifications