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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| B, Ch, M, R, H, Zebrafish | ELISA, ICC, IHC, IP, WB | Rb | Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB5620 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Neurogranin Antibody |
| Product Information | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purified immunoglobulin. Purified by ammonium sulfate precipitation. Liquid in PBS with 0.02% sodium azide as a preservative. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Anti-Neurogranin Antibody is validated for use in ELISA, IC, IH, IP, WB for the detection of Neurogranin. |
| Key Applications |
|
| Application Notes | Immunoblot: > 1:500-1:000 Immunohistochemistry: > 1:1,000 on 4% paraformaldehyde / PBS fixed or 3% Paraformaldehyde / 0.1% Gluteraldehyde / PBS fixed tissue sections. Immunocytochemistry: > 1:1,000. Immunoprecipitation: > 1:100 ELISA: > 1:2,000 Optimal working dilutions must be determined by the end user. |
| Biological Information | |
|---|---|
| Immunogen | Recombinant rat Neurogranin (complete sequence). |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Rabbit |
| Specificity | Recognizes Neurogranin. |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. |
| Gene Symbol |
|
| Purification Method | Ammonium Sulfate Precipitation |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: Q92686 # Acts as a third messenger substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). SIZE: 78 amino acids; 7618 Da SIMILARITY: SwissProt: Q92686 ## Belongs to the neurogranin family. & Contains 1 collagen-like domain. & Contains 1 IQ domain. |
| Molecular Weight | 7.5 kDa |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
| Packaging Information | |
|---|---|
| Material Size | 100 µL |