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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| Ma | ELISA, IP, RIA, WB | M | Purified | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MAB1617 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Kinesin Antibody, light chain, clone L2 |
| Product Information | |
|---|---|
| Format | Purified |
| Presentation | Liquid in 0.02 M Phosphate buffer, 0.25 M NaCl with 0.1% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Kinesin Antibody, light chain, clone L2 is an antibody against Kinesin for use in ELISA, IP, RIA & WB. |
| Key Applications |
|
| Application Notes | Immunoblotting Immunoprecipitation EIA/RIA Optimal working dilutions must be determined by the end user. Note: Does not work for immunohistochemistry and works only marginally for immunocytochemistry. |
| Biological Information | |
|---|---|
| Immunogen | Bovine brain kinesin. |
| Epitope | light chain |
| Clone | L2 |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Mouse |
| Specificity | Reacts with the light chain of kinesin near the C-terminal. |
| Isotype | IgG2a |
| Species Reactivity |
|
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined. |
| Gene Symbol |
|
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: Q07866 # Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. SIZE: 569 amino acids; 64786 Da SUBUNIT: Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9 (By similarity). TISSUE SPECIFICITY: Found in a variety of tissues. Mostly abundant in brain and spine. PTM: Isoform I is phosphorylated on Ser-596. SIMILARITY: SwissProt: Q07866 ## Belongs to the kinesin light chain family. & Contains 6 TPR repeats. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at 2-8°C in undiluted aliquots for up to 6 months. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |