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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| B, Ch, H, M, Rb, F, Fg | ELISA, WB | M | Purified | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MAB1691 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Troponin I Antibody, a.a. 186-192, clone C5 |
| Product Information | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purified immunoglobulin from Protein A Sepharose. Liquid in PBS pH 7.4 with 0.1% sodium azide as a preservative. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Detect Troponin I using this Anti-Troponin I Antibody, clone C5 validated for use in ELISA & WB. |
| Key Applications |
|
| Application Notes | Immunohistochemistry. The antibody is not recommended for use on parafin sections. Troponin sandwich ELISA (for labeling) with MAB3438. Western blotting. Recognizes a band at approxinmately 22.5 kDa corresponding to troponin I. Troponin I purification Optimal working dilutions must be determined by the end user. |
| Biological Information | |
|---|---|
| Immunogen | Bovine cardiac Troponin I. |
| Epitope | a.a. 186-192 |
| Clone | C5 |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Mouse |
| Specificity | Troponin I. Reacts with Troponin I from heart and skeletal muscle. |
| Isotype | IgG2b |
| Species Reactivity |
|
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | Troponin I (TnI) is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle; see also TNNI1 (MIM 191042). The others are troponin T (TnT; see MIM 191041) and troponin C (TnC; see MIM 191040).[supplied by OMIM] |
| Gene Symbol |
|
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P19429 # Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. SIZE: 210 amino acids; 24008 Da SUBUNIT: Binds to actin and tropomyosin. Interacts with TRIM63. DISEASE: SwissProt: P19429 # Defects in TNNI3 are the cause of familial hypertrophic cardiomyopathy type 7 (CMH7) [MIM:191044]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy [MIM:192600] is a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The prevalence of the disease in the general population is 0.2%. FHC is clinically heterogeneous, with inter- and intrafamilial variations ranging from benign to malignant forms with a high risk of cardiac failure and sudden cardiac death. & Defects in TNNI3 are the cause of familial restrictive cardiomyopathy (RCM) [MIM:115210]. RCM is an heart muscle disorder characterized by impaired filling of the ventricles with reduced volume in the presence of normal or near normal wall thickness and systolic function. The disease may be associated with systemic disease but is most often idiopathic. SIMILARITY: SwissProt: P19429 ## Belongs to the troponin I family. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain refrigerated at +2-8°C for up to 6 months. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |